Purpose:
The developed compounds are promising for the creation of effective anti-influenza drugs with minimal side effects.
Area:
Pharmacology, medicine.
Advantages:
Compared to traditional pharmaceuticals, the molecules of the developed compounds include components that are close in nature to those existing in a living organism, more bioavailable and less toxic. The toxicity of the proposed bis(citrate)germanate is less, and their effective dose is 5-10 times lower than the reference drug – Tamiflu (international name – oseltamivir). The conducted information and patent search showed that in the part of the invention, which concerns new chemical compounds and the method of their preparation, there are no analogues.
Description:
Methods have been developed and new coordination compounds based on germanium, citric acid and transition metals (cobalt and silver), proposed as low-toxic anti-influenza agents of a wide spectrum of action, have been developed for the first time. For new compounds, a pronounced antiviral activity has been established against the human influenza virus of strains A / Hong Kong / 1/68 (H3N2) and A / PR / 8/34 (H1N1), as well as the H5N3 avian influenza virus.