The event will take place at 16:00 Kyiv time.
Lecturer: Professor Remi Chauvin (Prof. Dr. Remi Chauvin), professor at the University of Toulouse, Toulouse, France.
He studied chemistry at the École Nationale Supérieure de Chemistry and the École Nationale Supérieure de Chemistry of Paris and received his PhD from the University of Paris-Saclay (University Paris XI). He worked as a postdoc, first in the group of B. Sharples at the Massachusetts Institute of Technology in the USA, and then at the University of Zurich in Switzerland. For 24 years he headed the laboratory of coordination chemistry at the University of Toulouse. His research interests include the study of carbobenzenes with different physical properties, the development of anticancer and antituberculosis lipid alkynylcarbinols, the study of electrostatic effects of polar phosphocarbonyl ligands in catalysis, and theoretical studies of the structure of organic compounds.
In 2019 he was awarded a medal of the National Academy of Sciences of Ukraine. He is an honorary doctor of the Scientific and Technical Complex “Institute of Single Crystals” of the National Academy of Sciences of Ukraine, Donetsk National University named after. Vasyl Stus and Kyiv National University. Taras Shevchenko.
Topic of the report: Controlled lipid acetylene cytotoxic agents (LAC) against cancer and tuberculosis. “Tunable Lipidic Acetylenic Cytotoxics (LACs) against Cancers and Tuberculosis”.
Continued interest in acetylene chemistry in the field of organic materials has drawn attention to the possibility of its use in the biomedical sciences. According to the literature, following the discovery of the antituberculosis metabolite mycomycin in 1947, lipid alkynylcarbinols (LACs) extracted from marine sponges were found to exhibit significant antitumor cytotoxicity. Structure-activity relationship studies on natural alkenylalkynylcarbinols (AAC) led to the discovery of the chiral pharmacophore dialkynylcarbinol (DAC or DACol). Subsequent modifications by introducing an alenyl group or an additional triple bond resulted in the formation of BAC compounds that were active at very low picomolar concentration levels. With the goal of stabilizing “pseudoaromatic” BACs, modulation has been generalized through the key “small synthon” strategy, which is expected to be applied in enantiopure series. Results regarding the cytotoxicity of artificial LACs to Mycobacterium tuberculosis will also be made public.
The language of the seminar is English.
Participation is free. Scientists, graduate students, students, teachers and everyone else are invited.
Lectures are held in communication mode.
Meeting ID: 459 004 2894
Passcode: Ch24022022
Event coordinator: Corresponding Member of the National Academy of Sciences of Ukraine, Professor Valentin Chebanov (chebanov@gmail.com; info@isc.kh.ua).
Briefly about the event:
April 21, 2024 marks two years since scientists of the Research Department of Chemistry of Functional Materials STC “Institute of Single Crystals” of the National Academy of Sciences of Ukraine began and is accessible to a wide range of people the Kharkiv Chemical Seminar, at which chemists give reports and lectures peace. Two years later, the Kharkov Chemical Seminar became a notable event among scientists. More than 45 lectures were held, which were joined by about 10,000 participants (directly at the meetings and through the YouTube channel). The course of lectures was given by Nobel laureates Jean-Marie Laine, Jean-Pierre Sauvage, Richard Roberts, Kurt Wüthrich, Dan Shechtman, as well as leading scientists from France, Switzerland, Austria, Germany, the USA, the Netherlands, Canada and other countries, in particular, Eric Careira, Phil Baran, Omar Yaghi, Yuri Gogotsi, Oliver Kappe and many others.
More details on the Institute’s website