GRANULAR HYDROGEL MATERIALS FOR CONTROLLED DRUG RELEASE SYSTEMS

PURPOSE:

To identify the negative side effects of drugs and their metabolic products on the human body.

DESCRIPTION:

Functionally active hydrogel materials in the form of granules with a diameter of 0.1-2 mm are biocompatible, thromboresistant, resistant to sterilization at elevated temperatures, have an increased immobilization ability to anionic drugs (for example, carbamazine 6 ∙ 10-3 g / g, heparin 500 thousand units / m2, p aminosalicylic acid 4 ∙ 10-3 g / g, etc.). Due to the characteristics of hydrogel materials in the intestinal environment, drugs are released at a constant rate, ensuring a constant concentration of the active substance in the body for the required time. The release rate and the magnitude of the sorption capacity are regulated by the chemical composition of the hydrogel, the diameter of the granules, and depends on the pH of the medium.

ADVANTAGES:

    • biocompatibility;
    • ease of elimination from the body without harmful side effects;
    • absence of toxic metabolic products;
    • long-term and constant drug release depending on the pH of the medium;
    • reduction of the required dose of drugs by 5-10 times.

RECOMMENDED FIELD OF APPLICATION:

Pharmaceutical industry.

 

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