Development of new therapeutic and prophylactic agents and pathogenetic substantiation of their use in inflammatory periodontal diseases against the background of metabolic syndrome

R&D registration number in UkrISTEI: 0120U002197

What priority area of science and technology does it correspond to: life sciences, new technologies for the prevention and treatment of the most common diseases.

Research: applied

Funding source: state budget; general fund of the state budget

Amount of financing: UAH 100–500 thousand (UAH 352.2 thousand)

Year of study start: 2020

The total duration of the study (according to the plan): 2020 – 2021.

Prospect for further implementation in 2022-2023: to be completed

Research level: no analogues in Ukraine

Availability of a patent: 1 patent of Ukraine.

Additional actions requiring further research in 2022: seeking interested investors.

Participation of the institution in the existing regional targeted and integrated programs: Program code 2301020 Scientific and scientific and technical activities in the field of healthcare.

Brief description, advantages, further prospects for application.

The characteristics of the complex action of a new treatment-and-prophylactic complex with the use of a new oral hygiene product on the clinical course of comorbid diseases against the background of the metabolic syndrome were determined. Methods for the topical application of new oral care products have been created to eliminate the pathogenic effects of the metabolic syndrome components on periodontal tissues, which make it possible to achieve an anti-inflammatory, antimicrobial, and regenerative effect in a short time. A treatment algorithm has been developed for patients with periodontal disorders, oral mucosa against the background of metabolic syndrome, which will allow the optimal implementation of a personalized rehabilitation strategy. The introduction of newly targeted therapeutic and preventive measures, as an accompaniment for patients with metabolic syndrome, will allow for the optimal timing of prevention and treatment of the first signs of changes with the withdrawal of risk factors, preventing complications, disability, reducing the time of medical and social rehabilitation and proves the corresponding social and advantage developments in the perspective of application.

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