Technology for producing an antimicrobial agent based on modified lysine

Purpose. The technology was developed to obtain an effective and safe antimicrobial agent and can be used in the creation of pharmaceutical compositions for the prevention and treatment of bacterial diseases and candidiasis.

Specifications. Modification (formalization) of the amino acid is carried out by dissolving 10 g of lysine hydrochloride in 1000 ml of distilled water, after which formaldehyde is added to the solution in an amount of 22-23 g. The mixture is stirred and left for 10 days at a temperature of 23-25 ​​oC. Then the solution is evaporated for 20 minutes in a water bath and adjusted to 1000 ml with distilled water. 7-8 g of polyvinylpyrrolidone are added to the resulting solution. Mix thoroughly. Separately weigh 2-3 g (in terms of dry residue) of chlorophyllipt and mix with 6-7 g of polysorbate-80. Molded lysine is added to the resulting mixture. Mix thoroughly, leave for 1 hour, filter the mixture.

Application area. Pharmacy, biotechnology

Advantages. The proposed technology is characterized by ease of implementation and the possibility of implementation on standard equipment in the industrial conditions of Ukraine. Allows the use of accessible, environmentally friendly and relatively cheap substances as raw materials. Allows you to obtain a pharmaceutical composition that has antimicrobial and antimycotic effects against antibiotic-resistant strains of bacteria and candida.

Description. The essence of the technology is to create an optimal composition with a modified version of the amino acid lysine and chlorophyll metal complexes, which has an antimicrobial and antimycotic effect against antibiotic-resistant strains of bacteria and candida. A technology is proposed for producing a combined pharmaceutical product from plant raw materials (chlorophylls of Eucalyptus viminalis Labill) in combination with a modified amino acid lysine, which has antimicrobial properties and low toxicity. The ratio of the active ingredients of the composition and excipients.

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