Purpose. To improve the treatment of local radiation skin ulcers, which combines the use of photodynamic therapy and injection around the perimeter of the ulcer with autologous platelet-rich plasma will provide a pronounced reparative effect, which will accelerate the healing of radiation skin ulcers.
Specifications. Photodynamic therapy was carried out using a photon apparatus “Barva-LED/630” with a photon radiation power (P) of 25 mW, a wavelength (maximum radiation absorption) of 630–650 nm, and a photon irradiation session duration of 30 min. session – 45 J/cm2. A 0.1% aqueous solution of methylene blue was used as a photosensitizer (PS). The production of autologous platelet-rich plasma was carried out by centrifuging blood for 10 minutes at a centrifuge speed of 1800 rpm. The top layer of platelet-rich plasma was taken into a separate tube and centrifuged again for 7 minutes at a centrifuge speed of 3000 rpm.
Application area. Medical radiology.
Advantages. The main advantages over existing technologies are that the technology allows accelerating the healing of radiation ulcers and restoring the primary structure of the lost part of the skin, in contrast to existing technologies, where only a pathological (hypertrophic or keloid) skin scar was formed.
Technical and economic effect. The social effect is to accelerate the healing of radiation ulcers and restore the primary structure of the lost part of the skin, due to the reduction of inflammatory changes in the lesion, activation of the processes of growth and maturation of granulation tissue, activation of proliferative processes in the epidermis, reduction in the severity of hemodynamic and cavity dermis, hypodermis and muscle tissue .
Description. The technology involves the use of photodynamic therapy (PDT) by exposing the affected area of skin to optical irradiation and assessing the rate of ulcer healing; 5 hours after the photodynamic therapy session, the ulcerative defect is additionally injected evenly intradermally around the perimeter with autologous plasma enriched for the injection, and this procedure is repeated after every 7 days until the ulcer is completely healed. To increase the effectiveness of treatment of local radiation skin ulcers, the use of photodynamic therapy (PDT) has been proposed by exposing the affected area of skin to optical radiation; 5 hours after the PDT session, the ulcer is punctured evenly. complete healing of the ulcer. The technology makes it possible to accelerate the healing of radiation ulcers and restore the primary structure of the lost part of the skin.