New generation compounds showing anti-influenza activity


The developed compounds are promising for the creation of effective anti-influenza drugs with minimal side effects.


Pharmacology, medicine.


Compared to traditional pharmaceuticals, the molecules of the developed compounds include components that are close in nature to those existing in a living organism, more bioavailable and less toxic. The toxicity of the proposed bis(citrate)germanate is less, and their effective dose is 5-10 times lower than the reference drug – Tamiflu (international name – oseltamivir). The conducted information and patent search showed that in the part of the invention, which concerns new chemical compounds and the method of their preparation, there are no analogues.


Methods have been developed and new coordination compounds based on germanium, citric acid and transition metals (cobalt and silver), proposed as low-toxic anti-influenza agents of a wide spectrum of action, have been developed for the first time. For new compounds, a pronounced antiviral activity has been established against the human influenza virus of strains A / Hong Kong / 1/68 (H3N2) and A / PR / 8/34 (H1N1), as well as the H5N3 avian influenza virus.

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